GraphTox: A Semi-Supervised Pre-Trained Framework for Peptide Toxicity Prediction using Geometric Graph Transformer and LORA-Based Finetuning (opens in new tab)

Peptides are widely used as potential therapeutic agents in drug discovery and biotechnology because they are specific, effective, and relatively inexpensive to produce. They are used in drug development, vaccines, and antimicrobial treatments. However, peptide toxicity remains a major concern as it offers unwanted toxic consequences, such as membrane rupture, haemolysis, tissue damage and adverse immunological response. Early detection of toxic peptide candidates is vital for the development...