Annotation-free sequence-level multimodal graph learning reveals gut microbiome signatures of atherosclerotic cardiovascular disease (opens in new tab)

Background: Atherosclerotic cardiovascular disease (ACVD) remains one of the leading causes of mortality, and the gut microbiome has been implicated in ACVD-related metabolic and inflammatory processes. However, current microbiome-based disease prediction frameworks predominantly rely on annotation-dependent taxonomic or pathway-level abundance profiles. While effective for community-level association analysis, these approaches compress metagenomic information into predefined biological categ...