Minimal Computational Framework for Systematic Identification of Antimicrobial Targets (opens in new tab)

Systematic identification of antimicrobial targets remains a major challenge, as discovery still relies largely on empirical, resource-intensive approaches with limited efficiency. We present a method for identifying antimicrobial targets based on protein dynamics, enabling rational polypharmacology. The approach spans multiple biological scales, from taxa (genus and species) to biological networks, including network hubs and edges, their constituent proteins, protein binding sites, and their...