An Integrated Computational Approach to Predict and Characterize Emerging Mutations in the Japanese Encephalitis Virus Envelope Protein (opens in new tab)

Japanese encephalitis virus (JEV) causes significant encephalitis across the Asia Pacific region. Current vaccines target historical genotype III strains, but emerging genotypes, potentially driven by vaccine-mediated selective pressure, threaten vaccine effectiveness through altered envelope protein sequences that may reduce antibody cross-neutralisation. This study employed integrated sequence and structural analyses to identify E protein mutations affecting neutralising antibody binding an...