Transcriptomics-Conditioned Virtual Tissue Synthesis via Diffusion Transformers (opens in new tab)

Spatial transcriptomics couples hematoxylin and eosin (H&E) tissue morphology with spatially resolved gene expression (GE). However, generative models that exploit this coupling to synthesize tissue images from transcriptomic profiles remain scarce. We present STMDiT (Spatial Transcriptomics and Morphology Diffusion Transformer), a diffusion transformer that synthesizes H&E histopathology patches conditioned jointly on morphological embeddings and transcriptomic profiles. Building on PixCell ...