MetworkPy A Python Package for Graph- and Information-theoretic Investigation of Metabolic Networks (opens in new tab)

We present MetworkPy, a python package for investigating in silico genome-scale models of metabolism (GSMM). By using novel graph- and information-theoretic methods to explore the feasible reaction flux space, MetworkPy quantifies network context and simulates metabolic relationships between sets of enzyme-encoding genes without imposing assumptions of optimal growth. To demonstrate utility, we used MetworkPy to identify metabolic features perturbed by the transcription factor ArgR, a known r...