SpatialDataAgent: Autonomous Spatial Omics Data Curation at Decade Scale (opens in new tab)

Fragmented metadata in spatial omics archives has rendered large volumes of multimodal molecular-histological data inaccessible as 'dark data'. Here, we introduce SpatialDataAgent, an agentic workflow for autonomous spatial omics data curation, combining schema-constrained evidence evaluation with a self-refining standardization agent. Applied to a decade of GEO records, SpatialDataAgent identified 769 paired H&E-spatial transcriptomics (ST) datasets, representing a 6.4-fold scale expansion o...