fourSynergy: Ensemble-based interaction calling on 4C-seq data using gradient-free optimization (opens in new tab)

Motivation: Chromatin organization plays a crucial role in gene regulation and is associated with various severe diseases like cancer. Since chromatin changes are potentially reversible, a deeper understanding of the alterations needs to be harnessed for the development of new therapies. Circular Chromosome Conformation Capture Sequencing (4C-seq) is a sequencing technique enabling the identification of chromatin interactions between genes and regulatory elements. This work aims to develop an...