Decoding Hierarchical Cell-Cell Communication in Spatial Multi-Omics with CellSTIC (opens in new tab)

Cell-cell communication helps to coordinate tissue development, homeostasis, and immune responses, but identifying signaling interactions within intact tissues remains difficult. Although single-cell transcriptomics has enabled systematic inference of ligand-receptor interactions, dissociation disrupts spatial context and limits the identification of bona fide local signaling and region-specific communication programs. Spatial transcriptomics and spatial multi-omics offer the opportunity to s...