TRACE: a graph-based workflow for TCR-epitope prioritization and tumor-reactive T-cell identification (opens in new tab)

Accurate prioritization of T-cell receptor (TCR)-epitope interactions and identification of tumor-reactive T cells are important but difficult steps in immunotherapy-oriented bioinformatics workflows. Existing methods typically address these tasks separately and either model TCR-epitope pairs as independent observations or rely primarily on transcriptomic signatures. In this study, we present TRACE (TCR-epitope pRioritization And T-Cell idEntification), a graph-based computational workflow th...