FlowTransOP: Distributional Translation of Omics Signatures via Constrained Deep Flow Matching (opens in new tab)

Observations from pre-clinical models rarely generalize to human patients, leading to many failures in clinical trials. Most existing methods cannot handle domains with non-overlapping features and no paired samples. Here, we developed FlowTransOP to translate biological observations across such domains without requiring 1-to-1 feature mappings and paired data, while providing a guideline for model selection across four translational regimes. We use flow matching to align full domain distribu...