Just Add Structure: Protein Language Models Combined with Structural Equivariance Excel at Protein Tasks (opens in new tab)

Accurate in silico prediction of protein properties, functional fitness, and mutational effects remains a central challenge in protein engineering and therapeutic design. While Protein Language Models (PLMs) successfully capture rich evolutionary and functional constraints from sequence data, they only indirectly encode the spatial and geometric information that fundamentally governs protein function. Consequently, state-of-the-art approaches typically rely on extensive fine-tuning, ensemblin...