HESTA: a curated and reusable database for the human early organogenesis spatiotemporal transcriptome atlas (opens in new tab)

Background Human organogenesis is orchestrated by precise spatiotemporal gene expression. Mapping these dynamic processes requires transcriptomic data that preserve native anatomical context across continuous developmental stages. Results We present a spatiotemporal transcriptome database of human embryogenesis, profiling 77 sagittal sections from 13 euploid embryos (CS12-CS23) using Stereo-seq, yielding 14,744,703 bin50 spots. The atlas annotates 50 organs and maps 198 molecularly distinct s...