Quantifying and Predicting the Difficulty of Multiple Sequence Alignment with AlDiScore (opens in new tab)

Multiple Sequence Alignment (MSA) constitutes an important and frequent operation in molecular sequence data analysis. There exist numerous tools, algorithms, and criteria to infer an MSA. This plethora of available approaches to MSA may induced an ensemble of divergent MSAs for the same underlying unaligned sequence set. Even a single MSA tool may infer distinct MSAs when varying the input parameters. Hence, when using a diversified set of MSA algorithms and parameterizations, the observed d...