Combining transcriptomic resolutions and machine learning strategies uncovers new OXPHOS genes in Caenorhabditis elegans (opens in new tab)

Assigning functions to genes remains a major challenge in biology, as a large fraction of genes remain unannotated despite the availability of complete genomes. Oxidative phosphorylation (OXPHOS), the primary source of ATP in eukaryotes, exemplifies this gap: although it has been extensively studied in mammals, our understanding of this process in other lineages remains limited. In general, research in other organisms has relied on the identification of sequence homologs of genes previously c...