GalaxyVS: Exploring 100-Billion Compounds in Seconds (opens in new tab)

We present GalaxyVS, a hardware-software co-designed virtual screening framework built to explore the 100-billion commercially accessible chemical space in seconds, deployed at the National Supercomputing Center in Tianjin. Built upon the dense vector retrieval paradigm of DrugCLIP, GalaxyVS bypasses the structural dependencies and computational overhead of classical docking to enable rapid screening against experimentally determined as well as geometrically feasible pockets on AlphaFold-pred...