UnBlender: validating individual analyses in respiratory bulk RNA-seq cell type deconvolution (opens in new tab)

Analysis of RNA-seq data of respiratory samples has contributed much to our understanding of lung disease. However, bulk RNA-seq data are dependent on both cell type composition and the transcriptional activity of these samples' constituent cells, which complicates interpretation. Cell type deconvolution is frequently used to estimate cell type proportions of bulk transcriptomic gene expression data and improve interpretation of bulk transcriptomics data. However, accuracy of the estimated ce...