Spatial Gene Set Enrichment Analysis with Applications to Spatially Resolved Transcriptomic Data (opens in new tab)

Spatially resolved transcriptomics enables the systematic characterization of spatial gene expression variation across tissue sections. Spatially variable genes within the same biological pathway often exhibit similar spatial expression patterns, reflecting shared biological functions and tissue organization. However, existing gene set enrichment analysis methods typically ignore this spatial dependence, which may reduce power to detect spatially organized pathways and limit the interpretabil...