De Novo Design and Computational Validation of a High-Affinity Peptide Inhibitor Targeting the HPV E1-E2 Interface (opens in new tab)

The oncogenic progression of high-risk Human Papillomavirus (HPV) strains relies fundamentally on the cooperative interaction between the E1 replicative helicase and the E2 origin-binding protein to initiate viral DNA amplification. Disrupting this essential protein-protein interaction presents a highly promising, yet clinically unrealized, therapeutic paradigm for treating established HPV infections prior to malignant transformation. This research presents a comprehensive computational pipel...