Handshake: Partner-Specific Protein-Protein Binding Site Prediction at Scale Using ProstT5 and Cross-Chain Attention (opens in new tab)

Partner-specific protein-protein binding site prediction, identifying which residues of a protein form the interface when bound to a specific partner, remains a challenging task with significant implications for drug discovery and understanding of protein structure and function. Existing computational methods are limited by small training datasets, inconsistent redundancy filtering, and reliance on three-dimensional structural information at test time. Here we present a sequence-only, partner...