A Transformer-derived transcriptomic score associates with ex-vivo drug response in AML (opens in new tab)

Background Drug-tolerant persister (DTP) cell states have been implicated in relapse across multiple cancers, including acute myeloid leukaemia (AML) [1,2]. Methods that score such states from transcriptomic data, generalise to held-out samples, expose calibrated probability outputs, and link predictions to candidate biology are useful for prioritising follow-up experimental work. Existing transcriptomic methods for scoring drug-tolerant or persister-like states largely rely on fixed gene sig...