Multi-Omics Study of Ancestry in Adults with Intracranial Cancers Glioma (MOSAIC) (opens in new tab)

Background: Most genomic studies of adult type diffuse gliomas have focused on predominantly European ancestry populations, limiting the generalizability of molecular classifications and precision medicine approaches. We assembled a multi institutional glioma cohort of diverse patients to investigate how germline ancestry, molecular subtypes, and mutational processes shape tumor biology and clinical outcomes. Methods: We analyzed 1,102 adults with WHO 2021 classified diffuse gliomas (IDH muta...