SpsB is a target of SOS-response inhibitor OXF-077 and regulates quinolone resistance emergence (opens in new tab)

Bradbury, Walsh, and Lanyon-Hogg use affinity-based protein profiling to identify SpsB as a target of the SOS-response inhibitor OXF-077 in MRSA. SpsB is then shown to modulate SOS activation and the frequency of resistance emergence to ciprofloxacin.