TarDis: Achieving robust and structured disentanglement of multiple covariates (opens in new tab)

Inecik et al. introduce TarDis, a deep generative model that disentangles multiple covariates in single-cell genomics into structured latent spaces. By jointly modeling categorical and continuous factors with ordered, interpretable representations, TarDis enhances data integration, supports counterfactual and hypothesis-driven analyses, and enables the exploration of complex cellular dynamics across diverse conditions.