State-dependent spatial maps for navigation (opens in new tab)

Internal behavioral states influence many brain circuits, with well-known effects in sensory areas. Less is known about how these states shape downstream navigation circuits, such as the medial entorhinal cortex and hippocampus, which construct spatial maps from grid and place cells. Emerging evidence suggests that these maps can spontaneously switch (‘remap’) in stable environments and that remapping is linked to behavioral changes that are state related. We consider the circuit mechanisms u...