Reduced Ghrelin Receptor Activity Improves Mitochondrial Function and Muscle Function in Aged Mice (opens in new tab)

Researchers here report a novel approach to improving mitochondrial function in aged muscle tissue, involving a reduction in the activity of the ghrelin receptor, either via gene knockout or by using an inverse agonist small molecule. It is interesting to note that while this improves muscle function, it fails to improve either muscle mass or longevity in the treated mice. One might expect to see enhanced mitochondrial function produce at least some effect on those parameters, but the data is...