Reviewing What is Known of Sex Differences in Response to Established Longevity Interventions (opens in new tab)

It is well established that females and males in mammalian (and many other) species exhibit meaningfully different trajectories of health and mortality in later life. It is also well established, at least in mice, that many of the interventions demonstrated to modestly slow aging have meaningfully different outcomes in males versus females. The question of why these differences exist has no satisfactory answer at the present time, however. There are a great many theories and potential contrib...