APOE2 Allele of APOE Makes Neurons More Resilient in Cell Cultures (opens in new tab)

The Apolipoprotein E (APOE) gene exhibits a small number of common sequence variants across the human population, of which the desirable APOE2 variant is associated with modestly greater longevity, and the undesirable APOE4 variant is associated with a sizable increase in the risk of Alzheimer's disease. APOE is one of only a few genes to exhibit a reliable correlation with human life expectancy that replicates in epidemiological data from multiple study populations. APOE is involved in the t...