Assessing Candidate IGF-1 Receptor Inhibitors for the Ability to Modestly Slow Aging in Mice (opens in new tab)

The collective influence on aging of insulin, insulin-like growth factor (IGF-1), growth hormone, and the receptors for these signal molecules is well studied. It is arguably the most well studied area of cellular biochemistry and metabolism in the context of aging, a central set of mechanisms that regulate the evolved trade-off between growth and maintenance, and which is strongly influenced by the equally well studied intervention of calorie restriction. Numerous animal studies have demonst...