Celastrol as an Exercise Mimetic to Modestly Slow Aging (opens in new tab)

Researchers continue to identify compounds that marginally affect aging in short-lived species. The Interventions Testing Program at the NIA continues to show that most of these have no effect on life span when rigorously assessed in mice. The few points of comparison we do have between mice and humans suggest that effects on life span in mice resulting from manipulation of metabolism become much smaller in humans. Long lived species do not have the same flexibility in metabolic determination...