PM20D1 Creates N-oleoyl-Leucine to Improve Clearance of Amyloid-β Aggregates by Microglia (opens in new tab)

Researchers here note a mechanism that encourages the innate immune cells known as microglia to better clear amyloid-β in the aging brain. The protein PM20D1 acts in the formation of N-acylamides, and generation of the product N-oleoyl-leucine encourages microglia to more efficiently remove amyloid-β aggregates. In animal models of Alzheimer's disease based on an excessive creation of amyloid-β aggregates this improves matters. As is usually the case, it remains to be seen as to whether this ...