Reviewing the Role of Advanced Glycation Endproducts in Aging and Age-Related Disease (opens in new tab)

Glycation arises from the interaction of sugars with proteins, decorating proteins with additional structures that alter their function. Advanced glycation endproducts (AGEs) are a broad class of glycated proteins. The presence of AGEs is a form of stress on cells and systems in the body; some forms drive chronic inflammation through interaction with the receptor for AGEs (RAGE), while other forms alter the structural properties of the extracellular matrix by cross-linking collagen and other ...