Reviewing What is Known of Mechanisms Driving Individual Variation in Longevity (opens in new tab)

It remains an open question as to whether anything discovered about the roots of individual variation in life expectancy within a species will give rise to usefully effective interventions to treat aging. Some researchers hold up the passage of late life aging in centenarians as a goal to aim for - but centenarians, while having evaded death for longer than most, are nonetheless greatly impacted by degenerative aging and exhibit significant dysfunction and mortality rates. We must aim higher,...