Sirtuin 1 as an Exerkine (opens in new tab)

Despite the failure to produce any useful approach to therapy based on upregulation of sirtuin 1 expression, and an entirely unhelpful hype cycle that came and went associated with those efforts, research into sirtuin 1 continues apace. In the example here, researchers connect sirtuin 1 expression to the improved metabolism following exercise. As is usual in matters of cellular biochemistry, connecting specific benefits to specific mechanisms is challenging; a great deal changes with exercise...