Sirtuin 6 Overexpression Reverses Age-Related Structural Changes in Nuclear DNA in Liver Cells (opens in new tab)

The expression of genes from nuclear DNA is determined by the structure of nuclear DNA, meaning which regions are spooled and inaccessible versus which regions are unspooled and accessible to transcription machinery. This is visible as the structure of chromatin in the cell nucleus, where chromatin is the name given to the complex structures formed by nuclear DNA and its supporting molecules such as histones. Epigenetic mechanisms control DNA structure by adding and removing decorations to DN...