DNA R-Loops in the Cytoplasm Drive Senescent Cell Inflammatory Signaling (opens in new tab)

The accumulation of senescent cells in aged tissues is harmful because these cells generate a potent mix of inflammatory signals known as the senescence-associated secretory phenotype, disruptive to tissue structure and function when sustained over the long term. Researchers are interested in finding ways to selectively suppress this signaling, which involves better understanding the mechanisms that promote it. Here, researchers find a way in which senescent cells provoke the well studied cGA...