FGF21 Gene Therapy Improves Health in Aged Mice (opens in new tab)

Increased FGF21 expression is essential to the life extension produced by the practice of calorie restriction. It is a part of the regulatory system governing the beneficial reaction to low levels of protein intake, an evolved response that helps to increase the odds of individuals surviving long winters and other periods of famine. Here, researchers report on the use of an FGF21 AAV gene therapy in mice to produce the sweeping improvements in health that are characteristic of most calorie re...