GRK2 Aggregation as a Cause of Mitochondrial Dysfunction in Alzheimer's Disease (opens in new tab)

Here researchers report on a novel form of pathological protein aggregation in the aging brain and evidence for it to contribute to mitochondrial dysfunction in Alzheimer's disease. This phosphorylated GRK2 aggregation is argued to be a downstream effect of the other well-known forms of protein aggregation in the condition, those involving amyloid-β and tau, though that remains to be definitively proven. Certainly, given the inability of clearance of amyloid-β to produce sizable effects on th...