Reducing Loss of Calcium Homeostasis to Treat Aging in Mice (opens in new tab)

Researchers here identify mechanisms downstream of faulty calcium metabolism that drive the harmful signaling of senescent cells that accumulate in aged tissues. Calcium metabolism is well studied in a number of contexts, and various drugs exist to adjust its operation in one way or another. Applying one of those drugs to aged mice results in a reduction in the harms done by senescent cells, improved health, and a 17% extension of life span. There will be many ways in which the presence of se...