Reviewing Exercise and Exercise Mimetics as an Approach to Slow Aging (opens in new tab)

Alongside calorie restriction, exercise represents the gold standard of proof for an intervention to slow degenerative aging. Sadly the research community has demonstrated all too few approaches that can robustly improve on exercise and physical fitness in the matter of aging, and none of those yet have compelling human data to support the extensive animal studies. Rapamycin and senolytics spring to mind as those with the greatest amount of data. Partial epigenetic reprogramming is also inter...