Reviewing What is Known of Klotho in Brain Aging (opens in new tab)

Klotho is one of the few robustly longevity-associated genes. The effects of increased klotho expression on life span in mice that are arguably large enough to be interesting even if one prefers more of a focus on damage repair in the treatment of aging. A number of companies are developing therapies based on either the delivery of klotho fragments shown to improve function in aged animals, or using gene therapies to promote klotho expression and secretion. While klotho is important in the ag...