Thrombospondin-1 Secreted by Senescent Cells Impairs Bone Regeneration (opens in new tab)

Thrombospondin-1 is a component of the senescence-associated secretory phenotype (SASP) produced by senescent cells. It has been shown in the past to induce blood-brain barrier dysfunction, but here researchers show that it also degrades mitochondrial function in macrophages, biasing those cells into the inflammatory M1 state. This in turn contributes to chronic inflammation and dysfunctional bone regeneration. The accumulation of senescent cells with age is known to be an important aspect of...