Hydrogen sulfide modulates gene networks in hypoxia/reoxygenation-stressed trophoblasts: insights from transcriptome profiling (opens in new tab)

IntroductionHydrogen sulfide is an endogenous gaseous signalling molecule with recognized roles in vascular regulation, redox homeostasis, and inflammation. In the placenta, H2S is essential for maintaining trophoblast function and promoting healthy vascular remodelling. Impaired H2S signalling has been implicated in placental disorders characterized by oxidative stress, particularly in preeclampsia. One of the principal drivers of oxidative stress in the placenta is H/R injury, which mimics ...