Integrative multi-cohort analysis of DNA methylation profiles for pancreatic ductal adenocarcinoma biomarker discovery and prognosis (opens in new tab)

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human malignancies, in part due to late diagnosis and the lack of robust molecular biomarkers. Although aberrant DNA methylation is a defining feature of PDAC, most studies rely on single cohorts, limiting reproducibility and biological interpretation. Here, we performed an integrative multi-cohort analysis of genome-wide DNA methylation profiles from four independent PDAC datasets generated on Illumina EPIC and HumanMethy...