Pharmacokinetics, molecular docking, and molecular dynamics simulation unveil novel lichen-derived scaffolds targeting PBP2a MRSA (opens in new tab)

IntroductionAntimicrobial resistance (AMR) is a major threat to global health. It reduces the effectiveness of current antibiotics and treatment for infectious diseases. The rise in AMR is mainly due to the overuse of antibiotics and the increased adaptability of harmful microorganisms. Among resistant bacteria, Methicillin-Resistant Staphylococcus aureus (MRSA) can resist an array of antibiotics. A key factor in resistance of MRSA is Penicillin-binding protein 2a (PBP2a). This protein decrea...