NbBayesLM: bayesian prediction of nanobody thermostability using protein language model (opens in new tab)

Nanobodies, single-domain antibodies derived from camelids, are promising biologics due to their small size and high stability. Accurate prediction of their thermostability is critical for therapeutic and diagnostic applications. Due to their ability to bind conformationally constrained epitopes that are typically inaccessible to conventional antibodies, nanobodies represent a uniquely valuable modality in therapeutic target engagement and drug discovery. Existing methods for predicting nanob...