Computational validation and network pharmacology reveal the cardioprotective and hypolipidemic potential of Arisaema Jacquemontii Blume via molecular docking, metadynamics, DFT, and MM/PBSA analyses (opens in new tab)

IntroductionDespite the recognized therapeutic value of plant-derived compounds, Arisaema jacquemontii Blume, a traditional Himalayan herb, remains largely unexplored for cardiovascular applications. Based on ethnomedicinal evidence and pharmacological studies demonstrating antioxidant and protein kinase inhibitory activities, which are closely associated with cardiovascular protection, we hypothesized that A. Jacquemontii Blume may exert cardioprotective effects through the modulation of oxi...