Explainable machine learning-based identification of transcriptomic biomarkers in CD1c+ dendritic cells for non-infectious uveitis: an integrative analysis of bulk RNA-seq data (opens in new tab)

IntroductionNon-infectious uveitis (NIU) is a leading cause of intraocular inflammation, and the underlying immunological mechanisms remain incompletely understood. This study aims to classify NIU at the molecular level and interpret its biological mechanisms by applying machine learning and explainable artificial intelligence (XAI) methods to transcriptomic data from CD1c+ conventional dendritic cells type 2 (cDC2) isolated from the peripheral blood of NIU patients.MethodsTwo independent coh...