Near infrared fluorophore specific for annexin A2 identifies peripheral nerve injury in a rodent transection model (opens in new tab)

IntroductionPeripheral nerve injuries (PNI) pose a major challenge in the intraoperative assessment of nerve viability. Wallerian degeneration (WD) is the degenerative process of axonal breakdown distal to the site of injury, with limited proximal extension, and progresses through spatiotemporally consistent stages facilitated by Schwann cell reprogramming and macrophage infiltration. We evaluated LS-301, a near-infrared (NIR) fluorophore previously used in human oncology trials, that targets...