Unfolded protein response in bronchopulmonary dysplasia: mechanisms, pathways, and therapeutic implications (opens in new tab)

Bronchopulmonary dysplasia (BPD) is a prevalent chronic lung disease in preterm infants, characterized by impaired alveolarization and abnormal vascular development. Growing evidence indicates that endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) are closely involved in the pathogenesis of BPD. Under hyperoxic conditions, excessive reactive oxygen species promote protein misfolding and accumulation within the endoplasmic reticulum, leading to activation of the three ...